The Thalamic Reticular Nucleus and Schizophrenia
نویسندگان
چکیده
منابع مشابه
The thalamic reticular nucleus and schizophrenia.
BACKGROUND The thalamic reticular nucleus (TRN) is a shell-shaped gamma amino butyric acid (GABA)ergic nucleus, which is uniquely placed between the thalamus and the cortex, because it receives excitatory afferents from both cortical and thalamic neurons and sends inhibitory projections to all nuclei of the dorsal thalamus. METHOD A review of the evidence suggesting that the TRN is implicated...
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Neurons of the thalamic reticular nucleus (TRN) provide inhibitory input to thalamic relay cells and generate synchronized activity during sleep and seizures. It is widely assumed that TRN cells interact only via chemical synaptic connections. However, we show that many neighboring pairs of TRN neurons in rats and mice are electrically coupled. In paired-cell recordings, electrical synapses wer...
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Mutual inhibition between the GABAergic cells of the thalamic reticular nucleus (RTN) is important in regulating oscillations in the thalamocortical network, promoting those in the spindle range of frequencies over those at lower frequencies. Excitatory inputs to the RTN from the cerebral cortex are numerically large and particularly powerful in inducing spindles. However, the extent to which c...
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The mediodorsal nucleus of the human thalamus is in a crucial position that allows it to establish connections with diverse cerebral structures, particularly the prefrontal cortex. The present review examines existing neurobiologic studies of the brains of people with and without schizophrenia that indicate a possible involvement of the mediodorsal nucleus in this psychiatric disorder. Studies ...
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In this paper we present an analysis of the visual sector of the Thalamic Reticular Nucleus (TRN) from 3, 6, 18, 24 and 30 month old Wistar rats using stereological methods. The volume density (Vv), the number of neurones per surface unit (Na) and the neurone numerical density (Nv) showed a progressive decrease between the 3rd and the 24th months as the animals aged, whereas a significant incre...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2010
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbq142